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The new line of biostimulating gels based on natural high viscosity polynucleotides for skin rejuvenation and protection.


Nucleofill is an injectable bio-remodeling treatment that uses polynucleotides to stimulate collagen and elastin production in the skin while providing long-lasting hydration and antioxidant support.

The biocompatible polynucleotides in Nucleofill rebuild the skin in 3 ways:

  • Boosting the production of collagen through the activation of fibroblast activity
  • Binding with water molecules to provide lasting hydration within the dermal matrix
  • Neutralizing harmful free radicals

Nucleofill Contains a Pure Concentration Of Polynucleotides

Polynucleotides are fragments of DNA and RNA present in all living organisms. Biocompatible with the human body, high molecular weight polynucleotides work within the dermal matrix to stimulate fibroblast activity and rebuild skin tissue. Polynucleotides are also associated with tissue hydration, as they can attach a large number of water molecules. Their antioxidant action combats free radicals and protects the skin from the effects of photoaging. Unlike fillers, Nucleofill is a bio-remodeling treatment that stimulates the skin to rejuvenate itself.     

How Does Nucleofill Work?

Nucleofill contains natural, high viscosity, high molecular weight polynucleotides. This injection treatment works in 3 ways:

Strengthening & Lifting Action The polynucleotides in Nucleofill have a twofold bio-stimulating effect:
    • They activate fibroblasts to boost type I collagen and elastin production, which improves skin elasticity
    • They are associated with the maturation of fibroblasts within myofibroblasts, which has a lifting and strengthening effect on the skin.

Hydrating Action

Polynucleotides work within the dermal matrix by binding to water molecules and providing longer-lasting moisture.

Antioxidant Action

Nucleofill has strong antioxidant properties that play a critical part in eliminating free radicals and shielding the skin from further damage.


  • Revitalizes and lifts the skin
  • Moisturizes dehydrated, tired skin
  • Improves skin density and elasticity
  • Firmer and more contoured visage
  • Improves fine lines and wrinkles
  • Eliminates free radicals in the skin

Who Will Be Suitable For Nucleofill Treatment?

Nucleofill is ideal for men and women over 25, who begin to notice the first signs of aging, such as the loss of volume and appearance of fine lines and wrinkles, and who wish to tighten, hydrate, and improve the quality of their skin. In the case of acne scarring, treatment can be started at an earlier age.

Nucleofill treatments address the following conditions:

  • Dehydrated, dull skin
  • Loss of skin tension and strength
  • Skin exposed to oxidative stress
  • Visible signs of aging, including skin laxity

Nucleofill Treatment Regime

The doctor will analyze and assess your skin condition and needs to determine the specific areas for treatment. Nucleofill can be used on its own or combine with other treatments for the best results. Once an anesthetic cream has been applied to numb the area, the Nucleofill is injected at 5 Bio Aesthetic Points (BAP) on each side of the face.

For optimal results, Nucleofill treatments are carried out in a series of 3 to 4 treatments, with an interval of 2-4 weeks between each treatment.

Frequently Asked Questions (FAQ)

Topical anesthetic cream is applied to numb the treatment area, minimizing the discomfort of the injection.

Most patients experience a mild discomfort and temporary unease, which is relative individual tolerance to fine injections. The injections sting briefly, and there may be swelling and mild soreness around the injection points for 1 to 3 days.

The main effects of Nucleofill are improved skin tone, hydration, and elasticity. Nucleofill does not volumize skin but restores skin’s vitality and youthful elasticity. The visible results are natural and do not change facial features.

For optimal results, Nucleofill is recommended in 3 to 4 successive treatments every 2 to 4 weeks.

The lifting effect of the treatment generally lasts up to 18 months.

Some transient swelling can be expected at the injection points, but this will usually settle within a day. Bruising may occur, as is the case with all injectable treatments, and should fade within 14 days.

Nucleofill is a bio-revitalizing treatment. Containing active polynucleotides, this product stimulates the production of collagen and elastin while moisturizing and protecting skin from free radical damage. Unlike dermal fillers, Nucleofill boosts the skin’s natural mechanisms to rebuild itself at a cellular level.    

Containing pure polynucleotides, Nucleofill works at a cellular level to rejuvenate the skin by boosting hydration and stimulating collagen and elastin synthesis. The polynucleotides also contribute to the maturation of myofibroblasts in the skin, which helps lifting effect. As a result of these bio-remodeling processes that occur within the dermis, skin becomes firmer, better hydrated, and more elastic. Moreover, polynucleotides combat free radicals that are associated with the signs of aging.    

One Nucleofill pre-filled syringe is 2mls of volume. 1-2 syringes may be required per treatment session. The first two sessions are done one month apart, and maintenance treatments every 6 to 9 months thereafter.

Profhilo Price in Singapore: $800 per syringe.

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